Multi-cohort study links job demands and sociodemographics to mortality and wellbeing

Dr. Prakash K.C. examined the impact of physical job demands on changes in self-rated health over time. Self-rated health is a subjective measurement of health where a research participant is asked to rate their own health on a given scale. For instance, the scale can range from ‘good’ and ‘average’ to ‘suboptimal’.
In Dr. K.C.’s study, people who experienced high physical job demands were 18% more likely to change the ratings of their own health from ‘good’ to ‘suboptimal’ as they aged compared with people who had less physically demanding jobs. Likewise, people who rated their health as ‘suboptimal’ in midlife were 52% more likely to maintain this perception of poor health years later if their work had been physically demanding.
Ms. Kamilia Tanjung’s research is on the relationship between physical job demands and all-cause mortality. Her study suggests that both men and women with moderate to high levels of physical work demands are more likely to die at relatively younger ages than their peers with low physical demands.
The most robust association in Tanjung’s study was found among men with physically moderate work, where the risk of death was 10%. Additionally, previous studies that have examined the same topic have yet to determine whether physical job demands could be just as detrimental for women’s survival in older age. However, the current study was able to show a negative impact on women.
Despite growing digitalisation work remains physical
Dr. K.C.’s and Ms. Tanjung’s findings are aligned with the health paradox theory. The theory indicates that while physical activity generally promotes an individual’s health, the health advantage seems to occur only in specific domains of life, such as leisure time, during daily activities and commuting. Occupational physical activity, however, is one domain of life where the well-known health benefits of physical activity do not seem to persist.
“Our findings could explain the inequalities in health and life expectancy that are observed worldwide. Physical job demands involve activities such as heavy lifting, carrying or pushing large objects and prolonged physical movements. These activities make up most of the tasks of lower grade or blue-collar occupations,” K.C. and Tanjung say.
Despite the growing trends of digitalisation and automation at work, jobs with moderate to high degrees of physical requirements remain the most common occupation for many people across the globe, including those in the most developed countries.
“Therefore, it is possible that the differences in overall health status within a country’s population are the result of exposure to heavy physical work,” K.C. and Tanjung state.
The conclusions of these studies were drawn from four existing longitudinal cohort studies on ageing in Finland, United Kingdom, France and the US. The number of participants included in the analyses ranged between 35,000 and 40,000 participants and they had been traced for over 25 years. Both studies utilised a novel two-stage individual participant data meta-analysis approach to address the research questions in the respective studies.
Reference to original studies and links to full texts
- Prakash KC, Stenholm S, Kyrönlahti S, Kulmala J, Tanjung K, Nosraty L, Leino-Arjas P, Goldberg M, Nygård CH, Kivimäki M, Neupane S. Sociodemographic and work-related determinants of self-rated health trajectories: a collaborative meta-analysis of cohort studies from Europe and the US. Scientific Reports. 2025 Feb 13;15(1):5394.
- Tanjung K, KC P, Kyrönlahti S, Goldberg M, Nygård CH, Neupane S. Associations of psychosocial and physical work demands with all-cause mortality: a pooled analysis of prospective cohort studies. International Journal of Epidemiology. 2025 Jun;54(3):dyaf045.
Photo: Jonne Renvall /Tampere UniversityThe IPD-MAD project and its researchers
K.C.’s and Tanjung’s recent work are part of the Individual Participant Data Meta-Analysis of Midlife Antecedents of Disease Burden (IPD-MAD) project directed by University Lecturer Subas Neupane.
Neupane received the funding for his project from the Research Council of Finland in 2021. The aim of the project is to study the multifaceted role of midlife working conditions as core determinants of health and disease in terms of musculoskeletal disorders, mental disorders, functional (dis)ability, self-rated health, comorbidities and all-cause mortality. The possible role of lifestyle factors in the association of working conditions on the trajectories of musculoskeletal and mental disorders, functional disability, self-rated health, all-cause mortality among aging workers is also investigated. To achieve this aim, the project uses pooled data from large multiple prospective cohorts from several European countries and the US.
Dr. K.C. is a senior research fellow in the Unit of Health Sciences (HES), Faculty of Social Sciences (SOC). He earned a PhD in Occupational Epidemiology from Tampere University. Prior to working in the IPD-MAD project, he was a senior researcher at the Department of Public Health of the University of Turku and the Stress Research Institute in Stockholm University, Sweden.
Ms. Tanjung is a doctoral researcher in Occupational Health and Gerontology at the Doctoral Programme in Health Sciences (HES, SOC). She is an alumna of Tampere University’s International Master’s Degree Programme in Public and Global Health. She received the Tampere University Academic Excellence scholarship to complete her master’s degree.
For more information about the project, please contact: subas.neupane [at] tuni.fi (subas[dot]neupane[at]tuni[dot]fi)





