Publications
2017
Kiamehr M, Viiri LE, Vihervaara T, Koistinen KM, Hilvo M, Ekroos K, Käkelä R, Aalto-Setälä K.
Lipidomic profiling of patient-specific iPSC-derived hepatocyte-like cells.
Dis Model Mech. 2017 Sep 1;10(9):1141-1153.
Kuusela J, Larsson K, Shah D, Prajapati C, Aalto-Setälä K.
Low extracellular potassium prolongs repolarization and evokes early afterdepolarization in human induced pluripotent stem cell-derived cardiomyocytes.
Biol Open. 2017 Jun 15;6(6):777-784. doi: 10.1242/bio.024216.
Vuorenpää H, Penttinen K, Heinonen T, Pekkanen-Mattila M, Sarkanen JR, Ylikomi T, Aalto-Setälä K.
Maturation of human pluripotent stem cell derived cardiomyocytes is improved in cardiovascular construct.
Cytotechnology. 2017 Apr 10. doi: 10.1007/s10616-017-0088-1.
2016
Laurila E, Ahola A, Hyttinen J, Aalto-Setälä K.
Methods for in vitro functional analysis of iPSC derived cardiomyocytes – Special focus on analyzing the mechanical beating behavior.
Biochim Biophys Acta. 2016 Jul;1863(7 Pt B):1864-72.
Ojala M, Prajapati C, Pölönen RP, Rajala K, Pekkanen-Mattila M, Rasku J, Larsson K, Aalto-Setälä K.
Mutation-Specific Phenotypes in hiPSC-Derived Cardiomyocytes Carrying Either Myosin-Binding Protein C Or α-Tropomyosin Mutation for Hypertrophic Cardiomyopathy.
Stem Cells Int. 2016;2016:1684792. doi:10.1155/2016/1684792
2015
Juhola M, Penttinen K, Joutsijoki H, Varpa K, Saarikoski J, Rasku J, Siirtola H, Iltanen K, Laurikkala J, Hyyrö H, Hyttinen J, Aalto-Setälä K
Signal analysis and classification methods for the calcium transient data of stem cell-derived cardiomyocytes
Comput Biol Med, 2015, 61:1–7
Kiviaho A, Ahola A, Larsson K, Kujala K, Pekkanen-Mattila M, Venäläinen H, Paavola K, Hyttinen J, Aalto-Setälä, K
Distinct electrophysiological and mechanical beating phenotypes of Long QT syndrome type 1 -specific cardiomyocytes carrying different mutations
IJC Heart & Vasculature, 2015, 8:19-31
Penttinen K, Swan H, Vanninen S, Paavola J, Lahtinen A-M, Kontula K, Aalto-Setälä K
Antiarrhythmic effects of Dantrolene in patients with catecholaminergic polymorphic ventricular tachycardia and replication of the responses using iPSC models
PLoS One, 2015, 10(5):e0135806
Penttinen K, Siirtola H, Ávalos-Salguero J, Vainio T, Juhola M, Aalto-Setälä K
Novel analysis software for detecting and classifying Ca2+ transient abnormalities in stem cell-derived cardiomyocytes
PLoS One, 2015, 10(8):e0135806
Kartasalo K, Pölönen R-P, Ojala M, Rasku J, Lekkala J, Aalto-Setälä K, Kallio P
CytoSpectre: a tool for spectral analysis of oriented structures on cellular and subcellular levels
BMC Bioinformatics, 2015, 16:344
Manzini, S, Viiri L, Marttila S, Aalto-Setälä K
A comparative view on easy to deploy non-integrating methods for patient-specific iPSC production
Stem Cell Rev, 2015, 11(6):900-908
2014
Ahola A, Kiviaho A, Larsson K, Honkanen M, Aalto-Setälä K, Hyttinen J
Video image-based analysis of single human induced pluripotent stem cell derived cardiomyocyte beating dynamics using digital image correlation
Biomed Eng Online, 2014, 13:39
2013
Toivonen S, Ojala M, Hyysalo A, Ilmarinen T, Rajala K, Pekkanen-Mattila M, Äänismaa R, Lundin K, Palgi P, Weltner J, Trokovic R, Silvennoinen O, Skottman H, Narkilahti S, Aalto-Setälä K, Otonkoski T
Comparative analysis of targeted differentiation of hiPSC and hESC reveals variability associated with incomplete transgene silencing in retrovirally derived hiPSC lines
Stem Cells Transl Med, 2013, 2(2):89-93
2012
Lahti A, Kujala V, Chapman H, Koivisto A-P, Pekkanen-Mattila M, Kerkelä E, Hyttinen J, Kontula K, Swan H, Conklin B, Yamanaka S, Silvennoinen O, Aalto-Setälä K
Model for long QT syndrome type 2 using human iPS cells demonstrates arrhythmogenic characteristics in cell culture
Dis Model Mech, 2012, 5(2):220-230