Research infrastructure

Systems physiology and modelling

Tampere University

Faculty of Medicine and Health Technology

Hervanta Campus

https://www.tuni.fi/en/research/met-core-facilities-and-services

Introduction

Computational "in-silico" modelling is an expanding area of biological and physiological research toolbox. We have strong expertise on modelling the biophysical systems from cells to organs and whole body level. This includes e.g modelling cardiac or neurnal system drug effects, bioelectric measurements and fields or biomechanical assessment of devices or cellualr functions. We can construct or use models based on compartmental tools as well as finite element models featuring also the geometries and time reletated events of meny physical and biophysical phenomena.

MET Core-facilities and Services

Paci, M., Pölönen, R. P., Cori, D., Penttinen, K., Aalto-Setälä, K., Severi, S., & Hyttinen, J. (2018). Automatic optimization of an in silico model of human iPSC derived cardiomyocytes recapitulating calcium handling abnormalities. Frontiers in physiology, 9, 709.

Lenk, K., Satuvuori, E., Lallouette, J., Ladrón-de-Guevara, A., Berry, H., & Hyttinen, J. A. (2020). A Computational Model of Interactions Between Neuronal and Astrocytic Networks: The Role of Astrocytes in the Stability of the Neuronal Firing Rate. Frontiers in Computational Neuroscience, 13, 92.

Tervonen, A., Ihalainen, T. O., Nymark, S., & Hyttinen, J. (2019). Structural dynamics of tight junctions modulate the properties of the epithelial barrier. PloS one, 14(4).

Böttrich, M., Tanskanen, J. M., & Hyttinen, J. A. (2017). Lead field theory provides a powerful tool for designing microelectrode array impedance measurements for biological cell detection and observation. Biomedical engineering online, 16(1), 85.

Halonen, S., Kari, J., Ahonen, P., Kronström, K., & Hyttinen, J. (2019). Real-time bioimpedance-based biopsy needle can identify tissue type with high spatial accuracy. Annals of biomedical engineering, 47(3), 836-851.

Narra, N., Valášek, J., Hannula, M., Marcián, P., Sándor, G. K., Hyttinen, J., & Wolff, J. (2014). Finite element analysis of customized reconstruction plates for mandibular continuity defect therapy. Journal of biomechanics, 47(1), 264-268.