Olli Yli-Harja
About me
Prof. Olli Yli-Harja is leading the Computational Systems Biology and Complex Systems group at Tampere University, where he works in close collaboration with Prof. Frank Emmert-Streib (TaU) on Data Science and Digital Twins, and Dr. Meenakshisundaram Kandhavelu (TaU) on drug repurposing. Dr. Yli-Harja is also an Affiliate Professor in Institute for Systems Biology (ISB), Seattle, where he has ongoing collaborations on complex systems with Dr Stuart Kauffman (ISB), and on AML Digital Twins with Dr Ilya Shmulevich (ISB). Prof. Yli-Harja has supervised 38 PhD theses. He is an expert in modeling and simulation of complex systems, including biological and medical systems, and software development digital twins.
Latest publications
Aberrant DNA methylation distorts developmental trajectories in atypical teratoid/rhabdoid tumors
Pekkarinen, M., Nordfors, K., Uusi-Mäkelä, J., Kytölä, V., Hartewig, A., Huhtala, L., Rauhala, M., Urhonen, H., Häyrynen, S., Afyounian, E., Yli-Harja, O., Zhang, W., Helen, P., Lohi, O., Haapasalo, H., Haapasalo, J., Nykter, M., Kesseli, J. & Rautajoki, K. J., 2024, In: Life science alliance. 7, 6, 18 p., e202302088.Research output: Contribution to journal › Article › Scientific › peer-review
Genomic characterization of IDH-mutant astrocytoma progression to grade 4 in the treatment setting
Rautajoki, K. J., Jaatinen, S., Hartewig, A., Tiihonen, A. M., Annala, M., Salonen, I., Valkonen, M., Simola, V., Vuorinen, E. M., Kivinen, A., Rauhala, M. J., Nurminen, R., Maass, K. K., Lahtela, S. L., Jukkola, A., Yli-Harja, O., Helén, P., Pajtler, K. W., Ruusuvuori, P., Haapasalo, J., & 3 others, Nov 2023, In: Acta Neuropathologica Communications. 11, 1, 20 p., 176.Research output: Contribution to journal › Article › Scientific › peer-review
Signaling landscape of mitochondrial non-coding RNAs
Mutharasu, G., Murugesan, A., Kondamani, S., Thiyagarajan, R., Yli-Harja, O. & Kandhavelu, M., 9 Jan 2023, (E-pub ahead of print) In: JOURNAL OF BIOMOLECULAR STRUCTURE AND DYNAMICS. 10 p.Research output: Contribution to journal › Article › Scientific › peer-review
Structural analysis of human G-protein-coupled receptor 17 ligand binding sites
Konda Mani, S., Thiyagarajan, R., Yli-Harja, O., Kandhavelu, M. & Murugesan, A., 2023, In: JOURNAL OF CELLULAR BIOCHEMISTRY. 124, 4, p. 533-544 12 p.Research output: Contribution to journal › Article › Scientific › peer-review
GPR17 signaling activation by CHBC agonist induced cell death via modulation of MAPK pathway in glioblastoma
Nguyen, P., Doan, P., Murugesan, A., Ramesh, T., Rimpiläinen, T., Candeias, N. R., Yli-Harja, O. & Kandhavelu, M., 15 Feb 2022, In: LIFE SCIENCES. 291, 8 p., 120307.Research output: Contribution to journal › Article › Scientific › peer-review
Molecular interaction study of novel indoline derivatives with EGFR-kinase domain using multiple computational analysis
Palanivel, S., Yli-Harja, O. & Kandhavelu, M., 2022, In: JOURNAL OF BIOMOLECULAR STRUCTURE AND DYNAMICS. 40, 16Research output: Contribution to journal › Article › Scientific › peer-review
Molecular modeling and dynamics studies of the synthetic small molecule agonists with GPR17 and P2Y1 receptor
Murugesan, A., Nguyen, P., Ramesh, T., Yli-Harja, O., Kandhavelu, M. & Saravanan, K. M., 2022, In: JOURNAL OF BIOMOLECULAR STRUCTURE AND DYNAMICS. 40, 23, p. 12908-12916 9 p.Research output: Contribution to journal › Article › Scientific › peer-review
P2Y1 agonist HIC in combination with androgen receptor inhibitor abiraterone acetate impairs cell growth of prostate cancer
Le, H. T. T., Murugesan, A., Candeias, N. R., Ramesh, T., Yli-Harja, O. & Kandhavelu, M., Feb 2022, In: APOPTOSIS. 27, p. 283–295 13 p.Research output: Contribution to journal › Article › Scientific › peer-review
Programmed cell death detection methods: a systematic review and a categorical comparison
Kari, S., Subramanian, K., Altomonte, I. A., Murugesan, A., Yli-Harja, O. & Kandhavelu, M., Aug 2022, In: APOPTOSIS. 27, 7-8, p. 482-508 27 p.Research output: Contribution to journal › Review Article › peer-review
PTPRD and CNTNAP2 as markers of tumor aggressiveness in oligodendrogliomas
Rautajoki, K. J., Jaatinen, S., Tiihonen, A. M., Annala, M., Vuorinen, E. M., Kivinen, A., Rauhala, M. J., Maass, K. K., Pajtler, K. W., Yli-Harja, O., Helén, P., Haapasalo, J., Haapasalo, H., Zhang, W. & Nykter, M., 18 Aug 2022, In: Scientific Reports. 12, 14083.Research output: Contribution to journal › Article › Scientific › peer-review