Responsibilities
- Head of Laboratory Unit
- Group leader of Intestinal Signalling and Epigenetics
Fields of expertise
Intestinal signalling mechanisms (inflammatory and hormonal), epigenetics and celiac disease pathogenesis
Research unit
Latest publications
Human intestinal organoid models for celiac disease research
Dotsenko, V., Sioofy-Khojine, A. B., Hyöty, H. & Viiri, K., 2023, Celiac Disease. Castellanos-Rubio, A. & Galluzzi, L. (eds.). Academic Press, p. 173-193 21 p. (Methods in Cell Biology; vol. 179).Research output: Chapter in Book/Report/Conference proceeding › Chapter › Scientific › peer-review
The Oral Transglutaminase 2 Inhibitor ZED1227 Accumulates in the Villous Enterocytes in Celiac Disease Patients during Gluten Challenge and Drug Treatment
Isola, J., Mäki, M., Hils, M., Pasternack, R., Viiri, K., Dotsenko, V., Montonen, T., Zimmermann, T., Mohrbacher, R., Greinwald, R. & Schuppan, D., Jun 2023, In: International Journal of Molecular Sciences. 24, 13, 10815.Research output: Contribution to journal › Article › Scientific › peer-review
G2/M checkpoint regulation and apoptosis facilitate the nuclear egress of parvoviral capsids
Mattola, S., Mäntylä, E., Aho, V., Salminen, S., Leclerc, S., Oittinen, M., Salokas, K., Järvensivu, J., Hakanen, S., Ihalainen, T. O., Viiri, K. & Vihinen-Ranta, M., 2022, In: Frontiers in cell and developmental biology. 10, December, 21 p., 1070599.Research output: Contribution to journal › Article › Scientific › peer-review
JAZF1-SUZ12 dysregulates PRC2 function and gene expression during cell differentiation
Tavares, M., Khandelwal, G., Muter, J., Viiri, K., Beltran, M., Brosens, JJ. & Jenner, RG., 31 May 2022, In: Cell Reports. 39, 9, 21 p., 110889.Research output: Contribution to journal › Article › Scientific › peer-review
Apolipoprotein A4 defines the villus-crypt border in duodenal specimens for celiac disease morphometry
Taavela, J., Viiri, K., Välimäki, A., Sarin, J., Salonoja, K., Mäki, M. & Isola, J., 29 Jul 2021, In: Frontiers in Immunology. 12, 10 p., 713854.Research output: Contribution to journal › Article › Scientific › peer-review
Genome-Wide Transcriptomic Analysis of Intestinal Mucosa in Celiac Disease Patients on a Gluten-Free Diet and Postgluten Challenge
Dotsenko, V., Mäki, M., Viiri, K., Oittinen, M., Taavela, J., Popp, A., Peräaho, M., Staff, S., Sarin, J., Leon, F. & Isola, J., 2021, In: Cellular And Molecular Gastroenterology And Hepatology. 11, 1, p. 13-32 20 p.Research output: Contribution to journal › Article › Scientific › peer-review
Polycomb Repressive Complex 2 Regulates Genes Necessary for Intestinal Microfold Cell (M Cell) Development
George, J. J., Oittinen, M., Martin-Diaz, L., Zapilko, V., Iqbal, S., Rintakangas, T., Arrojo Martins, F. T., Niskanen, H., Katajisto, P., Kaikkonen, M. U. & Viiri, K., 2021, In: Cellular And Molecular Gastroenterology And Hepatology. 12, 3, p. 873-889 17 p.Research output: Contribution to journal › Article › Scientific › peer-review
Prc2 regulated atoh8 is a regulator of intestinal microfold cell (M cell) differentiation
George, J. J., Martin‐Diaz, L., Ojanen, M. J. T., Gasa, R., Pesu, M. & Viiri, K., 2021, In: International Journal of Molecular Sciences. 22, 17, 9355.Research output: Contribution to journal › Article › Scientific › peer-review
Targeted deletion of keratin 8 in intestinal epithelial cells disrupts tissue integrity and predisposes to tumorigenesis in the colon
Stenvall, C. G. A., Tayyab, M., Grönroos, T. J., Ilomäki, M. A., Viiri, K., Ridge, K. M., Polari, L. & Toivola, D. M., 2021, In: CELLULAR AND MOLECULAR LIFE SCIENCES. 79, 10.Research output: Contribution to journal › Article › Scientific › peer-review
Extensive reprogramming of the nascent transcriptome during iPSC to hepatocyte differentiation
Viiri, L. E., Rantapero, T., Kiamehr, M., Alexanova, A., Oittinen, M., Viiri, K., Niskanen, H., Nykter, M., Kaikkonen, M. U. & Aalto-Setälä, K., 2019, In: Scientific reports. 9, 1, p. 3562 3562.Research output: Contribution to journal › Article › Scientific › peer-review