Laura Kananen
Oma esittely
I am PhD, Associate Professor (Docent of gerontology) performing research on aging at Tampere University, Finland and Karolinska institutet, Sweden. My research focuses on aging from various perspectives. Currently, my main research interests are population aging and longevity as well as self-rated health and frailty. The research is performed using various human populations in different countries and data types (survey, register, biological) as multiorganizational and multidisciplinary collaboration efforts.
As part of my research theme, Mechanisms and Applications of Comprehensive Health Indicators, COMP-HEALTH, I have studied and/or study, for example, comprehensive health indicators, including the frailty index, epigenetic age, telomeres, cell-free DNA level (a marker of cellular and tissue damage), and self-rated health, some of which also serve as indicators of the biological aging (BA) process. I am particularly interested in what each indicator represents—what they are truly reflecting, their theoretical background, and their utility in research and clinical practice. Read more about some studies in COMP-HEALTH: Biological age predicts cardiovascular disease morbidity and mortality and Tutkimus selvitti epigeneettisen kellon toiminnan taustasyitä.
One of my current projects, funded by the Sigrid Jusélius Foundation, Biological aging trends among Finns in the 21st century and the effects of health intervention (BioAgeFin) examines how populations age today: whether it is similar to ageing a few decades ago. The study investigates the causes and consequences of this phenomenon, as well as the ways in which ageing can be influenced. The work is performed in collaboration with Finnish Institute for Health and Welfare, THL, Finland, and Karolinska Institutet, Sweden.
Beside research activities, I am an active member of the FIRI-FIRE infrastructure (https://fire-infra.com/en/), and participate in the development of register-based research education at the national level together with various organisations in Finland (universities, research institutes, data permit authorities[Findata, Statistics Finland]).
Funding since 2024
KAKS, The Finnish Foundation for Municipal Development, Finland, PI of the work package: Inequalities in Population Health in Finland, a full population register study
Sigrid Juselius Foundation, Finland, Project PI, 'Biological aging trends among Finns in the 21st century and the effects of health intervention (BioAgeFin)', nationwide study including register and survey data
Karolinska Institutet’s Research Foundation, Sweden, Special grant for younger scientists, PI, Research theme: Comprehensive Assessment of Internal and External Factors in Patient Recovery (IE-FACT), a region-wide register study of geriatric patients
Åke & Annie Marie Lundbergs Foundation, Sweden, IE-FACT
Funding 2018-2023
In Finland: Tampere Tuberculosis Foundation, Päivikki and Sakari Sohlberg Foundation, Yrjö Jahnsson Foundation, Juho Vainio Foundation, Emil Aaltonen Foundation
Työtehtävät
- leading, planning and implementing scientific research
- supervising the projects, conceptualizing research ideas, formulating research questions, establishing collaborations at both national and international levels, writing research plans, managing permits for research [e.g., ethical permits and legal access rights for sensitive data]; supervising data management, statistical analyses, results interpretation, and dissemination of the findings in both national and international academic forums and to general public
- applying funding for the research
- academic teaching and supervision of undergraduate and post graduate students in Finland and Sweden
- relevant activities in the FIRI-FIRE infrastructure
Osaamisalueiden kuvaus
- 9/2025, Completed pedagogy course, Collaborative Development Project (5 ECTS), TAU, Finland
- 5/2023, Completed pedagogy course, Academic Supervision and Guidance (5 ECTS), TAU, Finland
- 2/2016, Completed pedagogy course, Teaching and learning in higher education (10 ECTS), TAU, Finland
Luottamustoimet
2026-2028 Board member, Gerontology Research Center (GEREC), TAU and University of Jyväskylä, Finland
Merkittävimmät julkaisut
Total number of peer-reviewed scientific publications: 48
- Incl. studies on aging and longevity using various register, survey and biological data from different countries in multidisciplinary collaborations
- Incl. phenomewide and genomewide studies
Preprints
Pauliina Halonen, Markus J Haapanen, Seppo Koskinen, Tuija Jääskeläinen, Mikaela von Bonsdorff, Johan G Eriksson, Rikke Lund, Sara Hägg, Juulia Jylhävä, Dorota Religa, Christian Molnár, Linda Enroth, Jenni Kulmala, Marja Jylhä, Laura Kananen. A comparison of self-rated health, frailty-index, and multimorbidity as mortality predictors: a multi-cohort study in Nordic 30+ populations. Under review in BMC Medical Informatics and Decision Making. Preprint available: https://doi.org/10.21203/rs.3.rs-8099259/v1
Christian Molnár, Maria Eriksdotter, Jonathan KL Mak, Oliver Pihl, Steven Nehme, Martin Annetorp, Sara Hägg, Dorota Religa, Laura Kananen. Clinical study on common infections and mortality among 40 000 geriatric patients hospitalized in Stockholm, Sweden. Under review in Scientific Reports. Preprint available https://doi.org/10.21203/rs.3.rs-7907149/v1
Peer-reviewed scientific articles
1. Linda Enroth, Laura Kananen, Ella Tapola, Jutta Pulkki. How are non-optimal air temperatures related to health care use among older populations in Europe? A systematic scoping review 2000-2025. Accepted in Scandinavian Journal of Public Health - Decision on Manuscript ID SPUB-LR-2025-0432.R1, May 2026.
2. Linda Enroth, Katariina Tuominen, Pauliina Halonen, Terhi Lampio, Laura Kananen, Saara Marttila, Maija Satamo, Juulia Jylhävä, Anu Siren. Tervaskannot 90+: Monitieteinen pitkittäistutkimus pitkäikäisyydestä. Accepted in scientific journal, Sosiaalilääketieteellinen Aikakauslehti (Finnish language), April 2026.
3. Bednorz A, Trybek P, Lundberg C, Richter-Laskowska M, Kananen L, Religa D. The utility of handwriting analysis and selected neuropsychological tests in the diagnosis of mild cognitive impairment in older patients. J Neuropsychol. 2026 Mar;20(1):196-219. doi: 10.1111/jnp.70022. https://bpspsychub.onlinelibrary.wiley.com/doi/10.1111/jnp.70022
4. Abzhandadze T, Hoang MT, Raaschou P, Norgren J, Mo M, Molnar C, Xu H, Kananen L, Åkerman M, Religa D, Eriksdotter M, Garcia-Ptacek S. Temporal trends in sex differences in dementia care-results from the Swedish registry for cognitive/dementia disorders, SveDem. Sci Rep. 2025 May 29;15(1):18890. doi: 10.1038/s41598-025-03055-y. https://www.nature.com/articles/s41598-025-03055-y
5. Rajić S, Delerue T, Ronkainen J, Zhang R, Ciantar J, Kostiniuk D, Mishra PP, Lyytikäinen LP, Mononen N, Kananen L, Peters A, Winkelmann J, Kleber ME, Lorkowski S, Kähönen M, Lehtimäki T, Raitakari O, Waldenberger M, Gieger C, März W, Harville EW, Sebert S, Marttila S, Raitoharju E. Regulation of nc886 (vtRNA2-1) RNAs is associated with cardiometabolic risk factors and diseases. Clin Epigenetics. 2025 Apr 29;17(1):68. doi: 10.1186/s13148-025-01871-7. https://link.springer.com/article/10.1186/s13148-025-01871-7
6. Tirkkonen A, Mak JKL, Eriksson JG, Halonen P, Jylhävä J, Hägg S, Enroth L, Raitanen J, Hovatta I, Jääskeläinen T, Koskinen S, Haapanen MJ, von Bonsdorff MB, Kananen L. Predicting cardiovascular morbidity and mortality with SCORE2 (OP) and Framingham risk estimates in combination with indicators of biological ageing. Age Ageing. 2025 Mar 28;54(4):afaf075. https://doi.org/10.1093/ageing/afaf075
7. Marttila S, Rajić S, Ciantar J, Mak JKL, Junttila IS, Kummola L, Hägg S, Raitoharju E, Kananen L. Biological aging of different blood cell types. Geroscience. 2024 Jul 26. doi: 10.1007/s11357-024-01287-w. https://link.springer.com/article/10.1007/s11357-024-01287-w
https://www.tuni.fi/fi/ajankohtaista/tutkimus-selvitti-epigeneettisen-kellon-toiminnan-taustasyita
8. Haapanen MJ*, Kananen L*, Mikkola TM, Jylhävä J, Wasenius NS, Eriksson JG, von Bonsdorff MB. Frailty in Midlife as a Predictor of Changes in Body Composition from Midlife into Old Age: A Longitudinal Birth Cohort Study. Gerontology. 2024;70(8):831-841. doi: 10.1159/000539204. (*equal contribution)
9. Mak JKL, Skovgaard AC, Nygaard M, Kananen L, Reynolds CA, Wang Y, Kuja-Halkola R, Karlsson IK, Pedersen NL, Hägg S, Soerensen M, Jylhävä J. Epigenome-wide analysis of frailty: Results from two European twin cohorts. Aging Cell. 2024 Feb 27:e14135. https://onlinelibrary.wiley.com/doi/10.1111/acel.14135
10. Kananen L, Molnár C, Ansker F, Kozlowska DJ, Hägg S, Jylhävä J, Religa D, Raaschou P. Anticoagulant treatment and COVID-19 mortality among older adults living in nursing homes in Sweden. Health Sci Rep. 2023 Nov 14;6(11):e1692. https://doi.org/10.1002/hsr2.1692
11. Mak JKL, Kananen L, Qin C, Kuja-Halkola R, Tang B, Lin J, Wang Y, Jääskeläinen T, Koskinen S, Lu Y, Magnusson PKE, Hägg S, Jylhävä J. Unraveling the metabolic underpinnings of frailty using multicohort observational and Mendelian randomization analyses. Aging Cell. 2023 May 15:e13868. doi: 10.1111/acel.13868. https://pubmed.ncbi.nlm.nih.gov/37184129/
12. Kananen L, Hong X, Annetorp M, Mak JKL, Jylhävä J, Eriksdotter M, Hägg S, Religa D. Health progression for Covid-19 survivors hospitalized in geriatric clinics in Sweden. PLoS One. 2023 Mar 22;18(3):e0283344. doi: 10.1371/journal.pone.0283344. https://pubmed.ncbi.nlm.nih.gov/36947542/
13. Marttila S, Tamminen H, Rajić S, Mishra PP, Lehtimäki T, Raitakari O, Kähönen M, Kananen L, Jylhävä J, Hägg S, Delerue T, Peters A, Waldenberger M, Kleber ME, März W, Luoto R, Raitanen J, Sillanpää E, Laakkonen EK, Heikkinen A, Ollikainen M, Raitoharju E. Methylation status of VTRNA2-1/nc886 is stable across populations, monozygotic twin pairs and in majority of tissues. Epigenomics. 2022 Sep;14(18):1105-1124. doi: 10.2217/epi-2022-0228. Epub 2022 Oct 5. https://www.futuremedicine.com/doi/10.2217/epi-2022-0228
14. Kananen L, Hurme M, Bürkle A, Moreno-Villanueva M, Bernhardt J, Debacq-Chainiaux F, Grubeck-Loebenstein B, Malavolta M, Basso A, Piacenza F, Collino S, Gonos ES, Sikora E, Gradinaru D, Jansen EHJM, Dollé MET, Salmon M, Stuetz W, Weber D, Grune T, Breusing N, Simm A, Capri M, Franceschi C, Slagboom E, Talbot D, Libert C, Raitanen J, Koskinen S, Härkänen T, Stenholm S, Ala-Korpela M, Lehtimäki T, Raitakari OT, Ukkola O, Kähönen M, Jylhä M, Jylhävä J. Circulating cell-free DNA in health and disease - the relationship to health behaviours, ageing phenotypes and metabolomics. Geroscience. 2022 Jul 21. https://doi.org/10.1007/s11357-022-00590-8
15. Mak JKL, Hägg S, Eriksdotter M, Annetorp M, Kuja-Halkola R, Kananen L, Boström AM, Kivipelto M, Metzner C, Bäck Jerlardtz V, Engström M, Johnson P, Lundberg LG, Åkesson E, Öberg CS, Olsson M, Cederholm T, Jylhävä J, Religa D. Development of an electronic frailty index for hospitalized older adults in Sweden. J Gerontol A Biol Sci Med Sci. 2022 Mar 18:glac069. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9678204/
16. Mak JKL, Eriksdotter M, Annetorp M, Kuja-Halkola R, Kananen L, Boström AM, Kivipelto M, Metzner C, Bäck Jerlardtz V, Engström M, Johnson P, Lundberg LG, Åkesson E, Sühl Öberg C, Olsson M, Cederholm T, Hägg S, Religa D, Jylhävä J. Two Years with COVID-19: The Electronic Frailty Index Identifies High-Risk Patients in the Stockholm GeroCovid Study. Gerontology. 2022 Nov 30:1-10. doi: 10.1159/000527206. https://doi.org/10.1159/000527206
17. Ämmälä AJ, Suvisaari J, Kananen L, Lönnqvist J, Ripatti S, Pirkola S, Paunio T, Hovatta I. Childhood adversities are associated with shorter leukocyte telomere length at adult age in a population-based study. Psychoneuroendocrinology. 2021 Aug;130:105276. https://doi.org/10.1016/j.psyneuen.2021.105276
18. Kananen L, Eriksdotter M, Boström AM, Kivipelto M, Annetorp M, Metzner C, Bäck Jerlardtz V, Engström M, Johnson P, Lundberg LG, Åkesson E, Sühl Öberg C, Hägg S, Religa D, Jylhävä J, Cederholm T. Body mass index and Mini Nutritional Assessment-Short Form as predictors of in-geriatric hospital mortality in older adults with COVID-19. Clin Nutr. 2021 Jul 29:S0261-5614(21)00360-5. https://doi.org/10.1016/j.clnu.2021.07.025
19. Kananen, L, Marttila, S. Ageing-associated changes in DNA methylation in X and Y chromosomes. Epigenetics & Chromatin 14, 33 (2021). https://doi.org/10.1186/s13072-021-00407-6
20. Kananen L, Enroth L, Raitanen J, Jylhävä J, Bürkle A, Moreno-Villanueva M, Bernhardt J, Toussaint O, Grubeck-Loebenstein B, Malavolta M, Basso A, Piacenza F, Collino S, Gonos ES, Sikora E, Gradinaru D, Jansen EHJM, Dollé MET, Salmon M, Stuetz W, Weber D, Grune T, Breusing N, Simm A, Capri M, Franceschi C, Slagboom PE, Talbot DCS, Libert C, Koskinen S, Bruunsgaard H, Hansen ÅM, Lund R, Hurme M, Jylhä M. Self-rated health in individuals with and without disease is associated with multiple biomarkers representing multiple biological domains. Nature Scientific Reports. 2021 Mar 17;11(1):6139. https://doi.org/10.1038/s41598-021-85668-7
21. Kananen L, Hurme M, Jylhä M, Härkänen T, Koskinen S, Stenholm S, Kähönen M, Lehtimäki T, Ukkola O& Jylhävä J. Circulating cell-free DNA level predicts all-cause mortality independent of other predictors in the Health 2000 survey. Nature Scientific Reports 10, 13809 (2020). https://doi.org/10.1038/s41598-020-70526-9
22. Kananen L, Marttila S. What makes us old? Biology of ageing and how it can be manipulated. Review. Duodecim 2019;135(11):1098-106. Language: Finnish. https://www.duodecimlehti.fi/duo14951
23. Marttila S, Nevalainen T, Jylhävä J, Kananen L, Jylhä M, Hervonen A, Hurme M. Human endogenous retrovirus HERV-K(HML-2) env expression is not associated with markers of immunosenescence. Exp Gerontol. 2017 Oct 15;97:60-63.
24. Nevalainen T, Kananen L, Marttila S, Jylhävä J, Mononen N, Kähönen M, Raitakari OT, Hervonen A, Jylhä M, Lehtimäki T, Hurme M. Obesity accelerates epigenetic aging in middle-aged but not in elderly individuals. Clin Epigenetics. 2017 Feb 14;9:20.
25. Nevalainen T, Kananen L, Marttila S, Jylhävä J, Jylhä M, Hervonen A, Hurme M. Increased Paternal Age at Conception Is Associated with Transcriptomic Changes Involved in Mitochondrial Function in Elderly Individuals. PLoS One. 2016 Nov 23;11(11):e0167028.
26. Kananen L, Marttila S, Nevalainen T, Kummola L, Junttila I, Mononen N, Kähönen M, Raitakari OT, Hervonen A, Jylhä M, Lehtimäki T, Hurme M, Jylhävä J. The trajectory of the blood DNA methylome ageing rate is largely set before adulthood: evidence from two longitudinal studies. Age (Dordr). 2016 Jun;38(3):65. https://doi.org/10.1007/s11357-016-9927-9
27. Jylhävä J, Kananen L, Raitanen J, Marttila S, Nevalainen T, Hervonen A, Jylhä M, Hurme M. Methylomic predictors demonstrate the role of NF-κB in old-age mortality and are unrelated to the aging-associated epigenetic drift. Oncotarget. 2016 Apr 12;7(15):19228-41.
28. Kananen L, Marttila S, Nevalainen T, Jylhävä J, Mononen N, Kähönen M, Raitakari OT, Lehtimäki T, Hurme M. Aging-associated DNA methylation changes in middle-aged individuals: the Young Finns study. BMC Genomics. 2016 Feb 9;17:103. https://doi.org/10.1186/s12864-016-2421-z
29. Kananen L, Nevalainen T, Jylhävä J, Marttila S, Hervonen A, Jylhä M, Hurme M. Cytomegalovirus infection accelerates epigenetic aging. Exp Gerontol. 2015 Dec;72:227-9.
30. Walsh KM, Codd V, Rice T, Nelson CP, Smirnov IV, McCoy LS, Hansen HM, Elhauge E, Ojha J, Francis SS, Madsen NR, Bracci PM, Pico AR, Molinaro AM, Tihan T, Berger MS, Chang SM, Prados MD, Jenkins RB, Wiemels JL; ENGAGE Consortium Telomere Group, Samani NJ, Wiencke JK, Wrensch MR. Longer genotypically-estimated leukocyte telomere length is associated with increased adult glioma risk. Oncotarget. 2015 Dec 15;6(40):42468-77.
31. Marttila S, Kananen L, Jylhävä J, Nevalainen T, Hervonen A, Jylhä M, Hurme M. Length of paternal lifespan is manifested in the DNA methylome of their nonagenarian progeny. Oncotarget. 2015 Oct 13;6(31):30557-67.
32. Nevalainen T, Kananen L, Marttila S, Jylhä M, Hervonen A, Hurme M, Jylhävä J. Transcriptomic and epigenetic analyses reveal a gender difference in aging-associated inflammation: the Vitality 90+ study. Age (Dordr). 2015 Aug;37(4):9814.
33. Marttila S, Kananen L, Häyrynen S, Jylhävä J, Nevalainen T, Hervonen A, Jylhä M, Nykter M, Hurme M. Ageing-associated changes in the human DNA methylome: genomic locations and effects on gene expression. BMC Genomics. 2015 Mar 14;16:179.
34. Marttila S, Nevalainen T, Kananen L, Jylhävä J, Jylhä M, Hervonen A, Ilonen J, Hurme M. Number of sons contributes to ageing-associated inflammation. Sci Rep. 2015 Feb 27;5:8631.
35. Marttila S, Jylhävä J, Kananen L, Hervonen A, Jylhä M, Hurme M. Molecular mechanisms associated with the strength of the anti-CMV response in nonagenarians. Immun Ageing. 2014 Jan 31;11(1):2.
36. Walsh KM, Codd V, Smirnov IV, Rice T, Decker PA, Hansen HM, Kollmeyer T, Kosel ML, Molinaro AM, McCoy LS, Bracci PM, Cabriga BS, Pekmezci M, Zheng S, Wiemels JL, Pico AR, Tihan T, Berger MS, Chang SM, Prados MD, Lachance DH, O'Neill BP, Sicotte H, Eckel-Passow JE; ENGAGE Consortium Telomere Group, van der Harst P, Wiencke JK, Samani NJ, Jenkins RB, Wrensch MR. Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk. Nat Genet. 2014 Jul;46(7):731-5.
37. Savolainen K, Eriksson JG, Kananen L, Kajantie E, Pesonen AK, Heinonen K, Räikkönen K. Associations between early life stress, self-reported traumatic experiences across the lifespan and leukocyte telomere length in elderly adults. Biol Psychol. 2014 Mar;97:35-42.
38. Codd V, Nelson CP, Albrecht E, Mangino M, Deelen J, Buxton JL, Hottenga JJ, Fischer K, Esko T, Surakka I, Broer L, Nyholt DR, Mateo Leach I, Salo P, Hägg S, Matthews MK, Palmen J, Norata GD, O'Reilly PF, Saleheen D, Amin N, Balmforth AJ, Beekman M, de Boer RA, Böhringer S, Braund PS, Burton PR, de Craen AJ, Denniff M, Dong Y, Douroudis K, Dubinina E, Eriksson JG, Garlaschelli K, Guo D, Hartikainen AL, Henders AK, Houwing-Duistermaat JJ, Kananen L, Karssen LC, Kettunen J, Klopp N, Lagou V, van Leeuwen EM, Madden PA, Mägi R, Magnusson PK, Männistö S, McCarthy MI, Medland SE, Mihailov E, Montgomery GW, Oostra BA, Palotie A, Peters A, Pollard H, Pouta A, Prokopenko I, Ripatti S, Salomaa V, Suchiman HE, Valdes AM, Verweij N, Viñuela A, Wang X, Wichmann HE, Widen E, Willemsen G, Wright MJ, Xia K, Xiao X, van Veldhuisen DJ, Catapano AL, Tobin MD, Hall AS, Blakemore AI, van Gilst WH, Zhu H; CARDIoGRAM consortium, Erdmann J, Reilly MP, Kathiresan S, Schunkert H, Talmud PJ, Pedersen NL, Perola M, Ouwehand W, Kaprio J, Martin NG, van Duijn CM, Hovatta I, Gieger C, Metspalu A, Boomsma DI, Jarvelin MR, Slagboom PE, Thompson JR, Spector TD, van der Harst P, Samani NJ. Identification of seven loci affecting mean telomere length and their association with disease. Nat Genet. 2013 Apr;45(4):422-7, 427e1-2.
39. Donner J, Sipilä T, Ripatti S, Kananen L, Chen X, Kendler KS, Lönnqvist J, Pirkola S, Hettema JM, Hovatta I. Support for involvement of glutamate decarboxylase 1 and neuropeptide Y in anxiety susceptibility. Am J Med Genet B Neuropsychiatr Genet. 2012 Apr;159B(3):316-27.
40. Tiainen AM, Männistö S, Blomstedt PA, Moltchanova E, Perälä MM, Kaartinen NE, Kajantie E, Kananen L, Hovatta I, Eriksson JG. Leukocyte telomere length and its relation to food and nutrient intake in an elderly population. Eur J Clin Nutr. 2012 Dec;66(12):1290-4.
41. Hovatta I, de Mello VD, Kananen L, Lindström J, Eriksson JG, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Peltonen M, Tuomilehto J, Uusitupa M. Leukocyte telomere length in the Finnish Diabetes Prevention Study. PLoS One. 2012;7(4):e34948.
42. Savolainen K, Räikkönen K, Kananen L, Kajantie E, Hovatta I, Lahti M, Lahti J, Pesonen AK, Heinonen K, Eriksson JG. History of mental disorders and leukocyte telomere length in late adulthood: the Helsinki Birth Cohort Study (HBCS). J Psychiatr Res. 2012 Oct;46(10):1346-53.
43. Kajantie E, Pietiläinen KH, Wehkalampi K, Kananen L, Räikkönen K, Rissanen A, Hovi P, Kaprio J, Andersson S, Eriksson JG, Hovatta I. No association between body size at birth and leucocyte telomere length in adult life--evidence from three cohort studies. Int J Epidemiol. 2012 Oct;41(5):1400-8.
44. Muiños-Gimeno M, Espinosa-Parrilla Y, Guidi M, Kagerbauer B, Sipilä T, Maron E, Pettai K, Kananen L, Navinés R, Martín-Santos R, Gratacòs M, Metspalu A, Hovatta I, Estivill X. Human microRNAs miR-22, miR-138-2, miR-148a, and miR-488 are associated with panic disorder and regulate several anxiety candidate genes and related pathways. Biol Psychiatry. 2011 Mar 15;69(6):526-33.
45. Eerola J, Kananen L, Manninen K, Hellström O, Tienari PJ, Hovatta I. No evidence for shorter leukocyte telomere length in Parkinson's disease patients. J Gerontol A Biol Sci Med Sci. 2010 Nov;65(11):1181-4.
46. Kananen L, Surakka I, Pirkola S, Suvisaari J, Lönnqvist J, Peltonen L, Ripatti S, Hovatta I. Childhood adversities are associated with shorter telomere length at adult age both in individuals with an anxiety disorder and controls. PLoS One. 2010 May 25;5(5):e10826.
47. Sipilä T, Kananen L, Greco D, Donner J, Silander K, Terwilliger JD, Auvinen P, Peltonen L, Lönnqvist J, Pirkola S, Partonen T, Hovatta I. An association analysis of circadian genes in anxiety disorders. Biol Psychiatry. 2010 Jun 15;67(12):1163-70.
48. Donner J, Pirkola S, Silander K, Kananen L, Terwilliger JD, Lönnqvist J, Peltonen L, Hovatta I. An association analysis of murine anxiety genes in humans implicates novel candidate genes for anxiety disorders. Biol Psychiatry. 2008 Oct 15;64(8):672-80.
Non-refereed scientific publications
Kananen Laura. DNA methylation states in supercentenarians. The Lancet Healthy Longevity. 2023. Volume 4, Issue 2, e57. https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00006-5/fulltext
Kananen Laura & Marttila Saara. 2023. Chapter 15: Theories of biological aging. In textbook, Gerontologia. Duodecim. Editors: Taina Rantanen, Katja Kokko, Sarianna Sipilä, Anne Viljanen. Language: Finnish. ISBN 9789523602465.
Thesis
Kananen L. PhD thesis. 2018. Tampere University. Aging-associated changes in the DNA methylome and characteristics of the epigenetic clock. http://urn.fi/URN:ISBN:978-952-03-0669-4