Martta Häkli
About me
I am a post doctoral researcher in professor Katriina Aalto-Setälä’s Heart Group. My research focuses on modeling hypertrophic cardiomyopathy (HCM) utilizing three-dimensional cardiac organoids generated from induced pluripotent stem cell derived cardiomyocytes and epicardial cells. My aim is to use the organoid model to investigate new mechanisms behind HCM.
Fields of expertise
Stem cell research, disease modeling, 3D cardiovascular tissue models
Research unit
Latest publications
Fluorescent hiPSC-derived MYH6-mScarlet cardiomyocytes for real-time tracking, imaging, and cardiotoxicity assays
Maria Cherian, R., Prajapati, C., Penttinen, K., Häkli, M., Koivisto, J. T., Pekkanen-Mattila, M. & Aalto-Setälä, K., 2023, In: Cell Biology and Toxicology. 39, 1, p. 145–163 19 p.Research output: Contribution to journal › Article › Scientific › peer-review
Electrophysiological Changes of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes during Acute Hypoxia and Reoxygenation
Häkli, M., Kreutzer, J., Mäki, A.-J., Välimäki, H., Cherian, R. M., Kallio, P., Aalto-Setälä, K. & Pekkanen-Mattila, M., Dec 2022, In: Stem Cells International. 2022, 15 p., 9438281.Research output: Contribution to journal › Article › Scientific › peer-review
Human Neurons Form Axon-Mediated Functional Connections with Human Cardiomyocytes in Compartmentalized Microfluidic Chip
Häkli, M., Jäntti, S., Joki, T., Sukki, L., Tornberg, K., Aalto-Setälä, K., Kallio, P., Pekkanen-Mattila, M. & Narkilahti, S., Mar 2022, In: International Journal of Molecular Sciences. 23, 6, 18 p., 3148.Research output: Contribution to journal › Article › Scientific › peer-review
Stem Cell-Based Cardiac Ischemia Model
Häkli, M., 2022, Tampere: Tampere University. (Tampere University Dissertations - Tampereen yliopiston väitöskirjat; vol. 640)Research output: Book/Report › Doctoral thesis › Collection of Articles
Human induced pluripotent stem cell-based platform for modeling cardiac ischemia
Häkli, M., Kreutzer, J., Mäki, A. J., Välimäki, H., Lappi, H., Huhtala, H., Kallio, P., Aalto-Setälä, K. & Pekkanen-Mattila, M., 2021, In: Scientific Reports. 11, 1, 4153.Research output: Contribution to journal › Article › Scientific › peer-review
Modeling Cardiac Ischemia with Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes
Häkli, M., Välimäki, H., Mäki, A., Kreutzer, J., Kattipparambil Rajan, D., Ryynänen, T., Kallio, P., Aalto-Setälä, K. & Pekkanen-Mattila, M., 2020.Research output: Other conference contribution › Scientific
Polyethylene Terephthalate Textiles Enhance the Structural Maturation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes
Pekkanen-Mattila, M., Häkli, M., Pölönen, R., Mansikkala, T., Junnila, A., Talvitie, E., Koivisto, J., Kellomäki, M. & Aalto-Setälä, K., 2019, In: Materials. 12, 11, p. E1805 16 p., 1805.Research output: Contribution to journal › Article › Scientific › peer-review