About me
Dr. Angela Serra is a University Lecturer at the Faculty of Medicine and Health Technology, Tampere University, Finland. She holds a Ph.D. in Computer Science and Information Engineering from the University of Salerno (2017). Her research focuses on the development of data and model integration strategies for chemical safety assessment and Safe and Sustainable by Design (SSbD). She is actively involved in EU research efforts and currently serves as a Work Package Leader in the INSIGHT project funded under Horizon Europe.
Selected publications
Serra A, Zouraris D, Schaffert A, Torres Maia M, Tsiros P, Virmani I, Di Lieto E, Saarimäki LA, Morikka J, Riudavets-Puig R, Varsou DD, Papavasileiou KD,
Kolokathis PD, Mintis DG, Tzoupis H, Tsoumanis A, Melagraki G, Arvanitidis A, Doganis P, Minadakis V, Savvas G, Perello-Y-Bestard A, Cucurachi S, Buljan M, Nikiforou F, Karakoltzidis A, Karakitsios S, Sarigiannis DA, Friedrichs S, Seitz C, Gutierrez TN, Isigonis P, Cambier S, Marvuglia A, Lindner GG, Sergent JA,
Gheorghe LC, Bradford LA, Park SG, Ha SM, Gerelkhuu Z, Yoon TH, Petry R, Martinez DST, Winkler DA, Wick P, Exner TE, Dondero F, Serchi T, Peijnenburg W, Sarimveis H, Paparella M, Lynch I, Afantitis A, Greco D. INSIGHT: An integrated framework for safe and sustainable chemical and material assessment. Comput Struct Biotechnol J. 2025 Mar 29;29:125-137. doi: 10.1016/j.csbj.2025.03.042.
Exner TE, Dokler J, Friedrichs S, Seitz C, Bleken FL, Friis J, Hagelien TF, Mercuri F, Costa AL, Furxhi I, Sarimveis H, Afantitis A, Marvuglia A, Larrea-
Gallegos GM, Serchi T, Serra A, Greco D, Nymark P, Himly M, Wiench K, Watzek N, Schillinger EK, Gavillet J, Lynch I, Karwath A, Haywood AL, Gkoutos GV, Hischier R. Going digital to boost safe and sustainable materials innovation markets. The digital safe-and-sustainability-by-design innovation approach of the PINK project. Comput Struct Biotechnol J. 2025 Mar 15;29:110-124. doi: 10.1016/j.csbj.2025.03.019.
Serra A, Fratello M, Federico A, Greco D. An update on knowledge graphs and their current and potential applications in drug discovery. Expert Opin Drug Discov. 2025 May;20(5):599-619. doi: 10.1080/17460441.2025.2490253. Epub 2025 Apr 14.
Maia, M. T., Fratello, M., del Giudice, G., Saarimäki, L. A., Möbus, L., Serra, A., & Greco, D. (2025). Nanomaterial grouping: Unraveling the relationship of induced mechanisms and potency at a temporal scale. Nano Today, 61, 102639.
Zouraris D, Mavrogiorgis A, Tsoumanis A, Saarimäki LA, Del Giudice G, Federico A, Serra A, Greco D, Rouse I, Subbotina J, Lobaskin V, Jagiello K,
Ciura K, Judzinska B, Mikolajczyk A, Sosnowska A, Puzyn T, Gulumian M, Wepener V, Martinez DST, Petry R, El Yamani N, Rundén-Pran E, Murugadoss S, Shaposhnikov S, Minadakis V, Tsiros P, Sarimveis H, Longhin EM, SenGupta T, Olsen AH, Skakalova V, Hutar P, Dusinska M, Papadiamantis AG, Gheorghe LC, Reilly K, Brun E, Ullah S, Cambier S, Serchi T, Tämm K, Lorusso C, Dondero F, Melagrakis E, Fraz MM, Melagraki G, Lynch I, Afantitis A. CompSafeNano project: NanoInformatics approaches for safe-by-design nanomaterials. Comput Struct Biotechnol J. 2024 Dec 25;29:13-28. doi: 10.1016/j.csbj.2024.12.024.
Migliaccio G, Morikka J, Del Giudice G, Vaani M, Möbus L, Serra A, Federico A, Greco D. Methylation and transcriptomic profiling reveals short term and long term regulatory responses in polarized macrophages. Comput Struct Biotechnol J. 2024 Aug 17;25:143-152. doi: 10.1016/j.csbj.2024.08.018.
Del Giudice G, Serra A, Pavel A, Torres Maia M, Saarimäki LA, Fratello M, Federico A, Alenius H, Fadeel B, Greco D. A Network Toxicology Approach for
Mechanistic Modelling of Nanomaterial Hazard and Adverse Outcomes. Adv Sci (Weinh). 2024 Aug;11(32):e2400389. doi: 10.1002/advs.202400389. Epub 2024 Jun 25.
Möbus L, Serra A, Fratello M, Pavel A, Federico A, Greco D. A Multi-Dimensional Approach to Map Disease Relationships Challenges Classical Disease
Views. Adv Sci (Weinh). 2024 Aug;11(30):e2401754. doi: 10.1002/advs.202401754. Epub 2024 Jun 5.
Del Giudice G, Migliaccio G, D'Alessandro N, Saarimäki LA, Torres Maia M, Annala ME, Leppänen J, Mӧbus L, Pavel A, Vaani M, Vallius A, Ylä-Outinen L,
Greco D, Serra A. Advancing chemical safety assessment through an omics-based characterization of the test system-chemical interaction. Front Toxicol. 2023 Nov 9;5:1294780. doi: 10.3389/ftox.2023.1294780.
Saarimäki LA, Fratello M, Pavel A, Korpilähde S, Leppänen J, Serra A, Greco D. A curated gene and biological system annotation of adverse outcome pathways related to human health. Sci Data. 2023 Jun 24;10(1):409. doi: 10.1038/s41597-023-02321-w. 16.
Saarimäki LA, Morikka J, Pavel A, Korpilähde S, Del Giudice G, Federico A, Fratello M, Serra A, Greco D. Toxicogenomics Data for Chemical Safety Assessment and Development of New Approach Methodologies: An Adverse Outcome Pathway-Based Approach. Adv Sci (Weinh). 2023 Jan;10(2):e2203984. doi: 10.1002/advs.202203984. Epub 2022 Dec 7.
Pavel A, Saarimäki LA, Möbus L, Federico A, Serra A, Greco D. The potential of a data centred approach & knowledge graph data representation in chemical safety and drug design. Comput Struct Biotechnol J. 2022 Sep 5;20:4837-4849. doi: 10.1016/j.csbj.2022.08.061.
Serra A, Del Giudice G, Kinaret PAS, Saarimäki LA, Poulsen SS, Fortino V, Halappanavar S, Vogel U, Greco D. Characterization of ENM Dynamic Dose-Dependent MOA in Lung with Respect to Immune Cells Infiltration. Nanomaterials (Basel). 2022 Jun 13;12(12):2031. doi: 10.3390/nano12122031.
Serra A, Saarimäki LA, Pavel A, Del Giudice G, Fratello M, Cattelani L, Federico A, Laurino O, Marwah VS, Fortino V, Scala G, Sofia Kinaret PA, Greco D.
Nextcast: A software suite to analyse and model toxicogenomics data. Comput Struct Biotechnol J. 2022 Mar 18;20:1413-1426. doi: 10.1016/j.csbj.2022.03.014.
Serra A, Fratello M, Federico A, Ojha R, Provenzani R, Tasnadi E, Cattelani L, Del Giudice G, Kinaret PAS, Saarimäki LA, Pavel A, Kuivanen S, Cerullo V,
Vapalahti O, Horvath P, Lieto AD, Yli-Kauhaluoma J, Balistreri G, Greco D. Computationally prioritized drugs inhibit SARS-CoV-2 infection and syncytia
formation. Brief Bioinform. 2022 Jan 17;23(1):bbab507. doi: 10.1093/bib/bbab507.
Pavel A, Del Giudice G, Federico A, Di Lieto A, Kinaret PAS, Serra A, Greco D. Integrated network analysis reveals new genes suggesting COVID-19 chronic
effects and treatment. Brief Bioinform. 2021 Mar 22;22(2):1430-1441. doi: 10.1093/bib/bbaa417.
Serra A, Fratello M, Del Giudice G, Saarimäki LA, Paci M, Federico A, Greco D. TinderMIX: Time-dose integrated modelling of toxicogenomics data.
Gigascience. 2020 May 1;9(5):giaa055. doi: 10.1093/gigascience/giaa055.
Serra A, Saarimäki LA, Fratello M, Marwah VS, Greco D. BMDx: a graphical Shiny application to perform Benchmark Dose analysis for transcriptomics data. Bioinformatics. 2020 May 1;36(9):2932-2933. doi: 10.1093/bioinformatics/btaa030.
Serra A, Önlü S, Festa P, Fortino V, Greco D. MaNGA: a novel multi-niche multi-objective genetic algorithm for QSAR modelling. Bioinformatics. 2020 Jan
1;36(1):145-153. doi: 10.1093/bioinformatics/btz521.
Serra A, Önlü S, Coretto P, Greco D. An integrated quantitative structure and mechanism of action-activity relationship model of human serum albumin
binding. J Cheminform. 2019 Jun 6;11(1):38. doi: 10.1186/s13321-019-0359-2.
Serra A, Letunic I, Fortino V, Handy RD, Fadeel B, Tagliaferri R, Greco D. INSIdE NANO: a systems biology framework to contextualize the mechanism-of-
action of engineered nanomaterials. Sci Rep. 2019 Jan 17;9(1):179. doi: 10.1038/s41598-018-37411-y.