Marja-Leena Linne
About me
Marja-Leena Linne is Professor of Medical Technology and Biotechnology at Tampere University and leads the Computational Neuroscience Research Group. Her research lies at the interface of neuroscience, biotechnology, and medical technology, where she develops experimental and computational approaches to understand brain function and disease.
Her group combines computational modeling, electrophysiology, advanced microscopy and artificial intelligence to investigate how interactions between neurons, glial cells, and the cerebral vasculature shape brain function, plasticity, learning, memory, and neuropsychiatric and neurological disorders. By integrating experimental data with biologically realistic multiscale models, the group develops multiscale simulation platforms and digital brain twins that support neuroscience research, neurotechnology, and future precision medicine. As a secondary research focus, the group explores how neurobiological mechanisms can inspire the development of energy-efficient algorithms and computational methods.
Linne contributes to the European research infrastructure EBRAINS and collaborates widely with international research, training, and education networks. She is committed to advancing interdisciplinary neuroscience by bringing together biotechnology, medical technology, engineering, computer science, and artificial intelligence.
Latest publications
Computational Modelling of Novelty Detection in the Mismatch Negativity Protocols and Its Impairments in Schizophrenia
Eissa, A., Fredrik Kismul, J., Pentz, A., Elvsåshagen, T., Metzner, C., Akkouh, I., Djurovic, S., Shadrin, A., Linne, M. L., Einevoll, G., Andreassen, O. & Mäki-Marttunen, T., Mar 2026, In: European Journal of Neuroscience. 63, 6, 20 p., e70453.Research output: Contribution to journal › Article › Scientific › peer-review
Scalable computational modeling of neuron-astrocyte interactions in NEST
Linne, M.-L., Jiang, H.-J., Acimovic, J., Manninen, T., Ahokainen, I., Stapmanns, J., Lehtimäki, M., Diesmann, M., van Albada, S. J. & Plesser, H. E., 2026.Research output: Other conference contribution › Abstract › Scientific
Simulation tools for reaction-diffusion modeling
Seppälä, S., Keto, L., Ndubuaku, D., Mäki, A., Mäki-Marttunen, T., Linne, M.-L. & Manninen, T., 2026, p. S301-S302.Research output: Other conference contribution › Abstract › Scientific
A unified model of short- and long-term plasticity: Effects on network connectivity and information capacity
Ahokainen, I. & Linne, M.-L., 7 Nov 2025.Research output: Working paper › Preprint › Scientific
Biochemically detailed modelling reveals genetic mechanisms for impaired synaptic plasticity in schizophrenia
Mäki-Marttunen, T., Blackwell, K. T., Akkouh, I., Shadrin, A., Valstad, M., Elvsåshagen, T., Linne, M.-L., Djurovic, S., Einevoll, G. T. & Andreassen, O. A., 2025.Research output: Other conference contribution › Abstract › Scientific
Computational modeling of neuron-astrocyte interactions: Tripartite connectivity and synaptic modulation
Plesser, H. E., Jiang, H.-J., Acimovic, J., Manninen, T., Ahokainen, I., Stapmanns, J., Lehtimäki, M., Diesmann, M., van Albada, S. & Linne, M.-L., 2025.Research output: Other conference contribution › Poster › Scientific
Computational modeling of tripartite connectivity and astrocyte-induced synaptic currents in neuronal networks
Linne, M.-L., Jiang, H.-J., Acimovic, J., Manninen, T., Ahokainen, I., Stapmanns, J., Lehtimäki, M., Diesmann, M., van Albada, S. J. & Plesser, H. E., 2025, p. E712-E713.Research output: Other conference contribution › Abstract › Scientific
Computational modelling of brain energy metabolism in schizophrenia
Mäkinen, I., Linne, M.-L. & Mäki-Marttunen, T., 4 Dec 2025.Research output: Other conference contribution › Abstract › Scientific
Computational modelling of brain energy metabolism in schizophrenia
Mäkinen, I., Linne, M.-L. & Mäki-Marttunen, T., 31 Oct 2025.Research output: Other conference contribution › Poster › Scientific
Computational modelling of brain energy metabolism in schizophrenia
Mäkinen, I., Linne, M.-L. & Mäki-Marttunen, T., 13 Feb 2025.Research output: Other conference contribution › Abstract › Scientific