Photo: Veronika Raibman
In his doctoral dissertation M.Sc. (Biol.) Tilman Tietz examined how nuclear-mitochondrial genetic interactions modulate the effects of mitochondrial insults in developing fruit fly larvae. The study demonstrates that chloramphenicol, an antibiotic that impairs translation at bacterial and mitochondrial ribosomes, reduces mitochondrial respiration and affects larval development and metabolism ππ π£ππ£π. Tietz documents that chloramphenicol induces a female-biased inheritable immune response in fly lines with specific nuclear-mitochondrial combinations and shows that the co-supplementation with the Bβ vitamer nicotinamide alleviates this outcome. The results illustrate that genetic variability influences the impact of mitochondrial insults and may contribute to the development of supportive interventions.
The doctoral dissertation of M.Sc. (Biol.) Tilman Tietz in the field of Life Sciences titled Mito-Nuclear Interactions Moderate the Impact of Chloramphenicol on Drosophila Immunometabolism will be publicly examined at the Faculty of Medicine and Health Technology at Tampere University on 5 June 2026.
The Opponent will be Professor Nick Lane from the University College London in the United Kingdom. The Custos will be Docent Tiina S. Salminen from the Faculty of Medicine and Health Technology, Tampere University.