Elina Mäntylä

My research interests include nuclear dynamics and nuclear mechanics to understand breast cancer invasiveness.

You can access my publications at researchportal.tuni.fi here: https://researchportal.tuni.fi/fi/persons/elina-m%C3%A4ntyl%C3%A4 

Our research group: https://research.tuni.fi/cellular-biophysics/about/ 

Tutkimukseni keskittyy tuman dynamiikkaan ja tuman mekaniikkaan, ja miten ne vaikuttavat rintasyövän invasiivisuuteen.

Julkaisuni tutkimusportaalissamme researchportal.tuni.fi ovat nähtävillä täältä: https://researchportal.tuni.fi/fi/persons/elina-m%C3%A4ntyl%C3%A4 

Tutkimusryhmämme löydät täältä: https://research.tuni.fi/cellular-biophysics/about/ 

Epithelial carcinomas are the most common cancer types worldwide. Failures to prevent their progression present an important economic burden. During the past decade, we have learned that mechanical forces affect tumorigenesis, invasion and metastatic processes in cancer. Importantly, recent findings underline the importance of mechanical forces in nuclear remodeling including nuclear envelope deformation, and changes in nuclear lamina mediated interactions affecting chromatin organization and gene expression. The main aim of my research is to understand in detail how nuclear envelope and especially nuclear lamina co-regulates chromatin organization, transcription and signaling processes under increased lateral compressive force in healthy and cancerous cells. The findings of my study aim to deepen the current knowledge on the causal connections between compressive forces and cell fate, and to understand the role of biophysical modulation in the progression of breast cancer.

Cellular biophysics, mechanobiology, nuclear mechanics, cancer biology, cell and molecular biology.