José María González de Cózar: Identifying novel mechanisms required for mitochondrial function
González de Cózar´s doctoral thesis focused on identifying the role of three proteins encoded in the nucleus that appeared to have an impact on mitochondrial function.
To investigate the roles of these proteins (Bet1, Slh, and RNase H1), a fruit fly (Drosophila) model was used. The project revealed that these three proteins are required to maintain the mitochondrial function, as severe mitochondrial defects were seen when these proteins were limited. The thesis sheds light on another once poorly described mitochondrial function and details the biochemical properties of the ribonuclease.
Altogether, the findings underline that even though the scientific community has investigated mitochondria for more than a century, our understanding of mitochondrial functions and requirements are still far from complete.
The doctoral dissertation of MSc. José María González de Cózar in the field of molecular biology and biochemistry titled Investigating the roles of three proteins in mitochondrial homeostasis will be publicly examined in the Faculty of Medicine and Health Technology at Tampere University at 12:00 on Friday 7 May 2021. The Opponent will be Professor Juhan Sedman from Tartu University, Estonia. Professor Howard T. Jacobs will act as the custos.
The event cn be followed via remote connection
The dissertation is available online at