Research focus and goals
The Laboratory of Biosystem Dynamics (LBD) of the Faculty of Medicine and Health Technology of Tampere University investigates the dynamics and regulatory mechanisms of bacterial gene expression, from individual transcriptional events and promoter architectures to genome-wide regulatory networks.
We combine live single-cell measurements, genome-wide profiling, synthetic gene engineering, mechanistic computational modelling, and biosignal processing. We apply microscopy, flow cytometry, RNA sequencing, fluorescent reporter libraries, multiscale stochastic models, and signal and image analysis. We focus on Escherichia coli and Klebsiella pneumoniae, and study how gene regulatory structures shape bacterial responses to environmental and antibiotic stresses.
Our goal is to identify principles connecting the mechanisms of transcription with the adaptive behaviors of gene networks to antibiotics stresses. That knowledge will assist revealing regulatory vulnerabilities and design principles to assist therapeutical and biotechnological efforts.
Contact persons
Andre Ribeiro, Professor
Principal Investigator
andre.sanchesribeiro [at] tuni.fi